Edit |   |
---|---|
Antigenic Specificity | GSK3B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3alpha and Ser9 of GSK-3beta (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). |
Immunogen | Immunogen: A synthetic peptide of human GSK3B Calculated Molecular Weight: 48kDa |
Other Names | [GSK3B; GSK3beta], [GSK3B; GSK3B; GSK-3 beta] |
Gene, Accession # | [GSK3B], Gene ID: 2932, NCBI: P49841.2, UniProt: P49841 |
Catalog # | MBS127304 |
Price | $200, $275, $430 |
Order / More Info | GSK3B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |