MARCH8 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MARCH8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MARCH8 Antibody: MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ub |
| Immunogen | Immunogen: MARCH8 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human MARCH8. Buffer: MARCH8 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [MARCH8; MIR; c-MIR; RNF178; MARCH-VIII; MIR; E3 ubiquitin-protein ligase MARCH8; Cellular modulator of immune recognition; membrane-associated ring finger (C3HC4) 8], [MARCH8; MARCH8; MIR; CMIR; c-MIR; RNF178; MARCH-VIII; MIR; RNF178; c-MIR; MARCH-VIII] |
| Gene, Accession # | [MARCH8], Gene ID: 220972, NCBI: NP_659458, UniProt: Q5T0T0 |
| Catalog # | MBS150557 |
| Price | $375 |
| Order / More Info | MARCH8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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