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Antigenic Specificity | CASP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspase-1, or interleukin-1beta converting enzyme (ICE/ICEalpha), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1beta and interferon-gamma inducing factor (IL-18) into their mature forms (1,2). Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-terminal pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis (3). Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1beta and are resistant to endotoxic shock (4,5). |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [CASP1; ICE; IL1BC; P45; Caspase-1], [CASP1; CASP1; ICE; P45; IL1BC; IL1BC; IL1BCE; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme] |
Gene, Accession # | [CASP1], Gene ID: 834, NCBI: P29466.1, UniProt: P29466 |
Catalog # | MBS127894 |
Price | $200, $275, $430 |
Order / More Info | CASP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |