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Antigenic Specificity | PLEC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PLEC antibody detects endogenous levels of total PLEC. Function: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.Subunit Structure: Homodimer or homotetramer. Interacts (via actin-binding domain) with SYNE3. Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region) (By similarity). Interacts (via N-terminus) with DST isoform 2 (via N-terminus) (P |
Immunogen | Immunogen: A synthesized peptide derived from human PLEC Subcellular Location: Cytoplasm > Cytoskeleton. Cell Junction > Hemidesmosome. Tissue Specificity: Widely expressed with highest levels in muscle, heart, placenta and spinal cord. Predicted Cross Reactivity: Bovine, Horse Similarity: Bovine (100%), Horse (100%) |
Other Names | [EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; pleC; PLEC_HUMAN; PLEC1; PLEC1b; Plectin 1; Plectin 1 intermediate filament binding protein 500kDa; Plectin 6; Plectin; Plectin-1; PLTN] |
Gene, Accession # | [PLEC], Gene ID: 5339, NCBI: NP_000436.2, UniProt: Q15149 |
Catalog # | MBS9608227 |
Price | $240, $280 |
Order / More Info | PLEC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |