Description | Caveolins are a family of integral membrane proteins which are the principal components of caveolae membranes and involved in receptor-independent endocytosis.[1], they are found in the majority of adherent, mammalian cells, and played an important role during the development of atherosclerosis.[2] Caveolin 1(CAV1) is a member of Caveolin gene family, and most prominently expressed in endothelial, fibrous and adipose tissue. It contains 3 exons spanning about 22 kD. It can link the integrin alpha subunit to the tyrosine kinase as a membrane adaptor[3]. |
Product Specific References | 1. Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF, Lisanti MP (January 1996). Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 131-5. 2. Williams TM, Lisanti MP (2004). The Caveolin genes: from cell biology to medicine. Ann. Med. 36 (8): 584-95. 3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C. Elevated expression of caveolin is associated with prostate and breast cancer. Clin. Cancer Res. 4: 1873-1880, 1998. |