TNAP1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TNAP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: TNAP1 antibody detects endogenous levels of total TNAP1. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.Subunit Structure: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. I |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes. Tissue Specificity: By TNF, IL1B/interleukin-1 beta and bacterial lipopolysaccharides (LPS). Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken Similarity: Pig (90%), Bovine (90%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (80%) |
| Other Names | [alpha-induced protein 1; BACD2_HUMAN; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; endothelial; hBACURD2; Protein B12; tnfaip1; Tumor necrosis factor alpha induced protein 1 (endothelial); Tumor necrosis factor alpha induced protein 1; Tumor necrosis factor] |
| Gene, Accession # | [TNAP1], Gene ID: 7126, NCBI: NP_066960.1, UniProt: Q13829 |
| Catalog # | MBS9604733 |
| Price | $240, $280 |
| Order / More Info | TNAP1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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