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Antigenic Specificity | GSK-3alpha |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human/Mouse GSK-3alpha. Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility. |
Immunogen | Immunogen: Recombinant N-terminal GSK-3alpha. Conjugation: HRP (Horseradish Peroxidase) |
Other Names | n/a |
Gene, Accession # | [GSK-3alpha] |
Catalog # | MBS679337 |
Price | $435 |
Order / More Info | GSK-3alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Meares GP, Zmijewska AA, Jope RS. HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation. Cell Signal. 2008;20:347-58. (IP)2. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (IP) |