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Antigenic Specificity | PPP2CA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PPP2CA antibody detects endogenous levels of total PPP2CA. Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.Subunit Structure: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates wit |
Immunogen | Immunogen: A synthesized peptide derived from human PPP2CA Subcellular Location: Cytoplasm. Nucleus. Chromosome > Centromere. Cytoplasm > Cytoskeleton > Spindle Pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2. |
Other Names | [PP2A alpha; PP2A-alpha; PP2AA_HUMAN; PP2Aalpha; PP2Ac; PP2CA; PP2Calpha; PPP2CA; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2, catalytic subunit, alpha isozyme; Protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP C; RP-C; RPC; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform] |
Gene, Accession # | [PPP2CA], Gene ID: 5515, NCBI: NP_002706.1, UniProt: P67775 |
Catalog # | MBS9608229 |
Price | $240, $280 |
Order / More Info | PPP2CA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |