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Antigenic Specificity | p63 (Squamous, Basal and Myoepithelial Cell Marker) |
Clone | [TP63/1786] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG2b, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC |
Immunogen | Immunogen: Recombinant human p63 protein fragment (aa3-106) Cellular Localization: Nuclear |
Other Names | [Amplified in squamous cell carcinoma (AIS); Chronic ulcerative stomatitis protein (CUSP); EEC3; Keratinocyte transcription factor KET; LMS; NBP; p40; P51/P63; p53 like transcription factor; p53-related protein p63; RHS; SHFM4; TAp63alpha; TP53CP; TP53L; TP63; TP73; TP73L; Transformation-related protein 63; Trp53rp1; Trp6; 3; Tumor protein 63; Tumor protein p53-like; tumor protein p73-like] |
Gene, Accession # | [p63], Gene ID: 8626, NCBI: NP_001108450.1, UniProt: Q9H3D4 |
Catalog # | MBS4380297 |
Price | $190, $340, $340 |
Order / More Info | p63 (Squamous, Basal and Myoepithelial Cell Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Yang A, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998; 2(3):305-16. |