actin gamma-cytoplasmic Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-actin gamma-cytoplasmic antibody, protein, ELISA kits.
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| Antigenic Specificity | actin gamma-cytoplasmic |
| Clone | [2A3] |
| Host Species | Mouse |
| Reactive Species | chicken, human, mouse, rabbit, rat, porcine, zebrafish |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) (frozen), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: 2A3 is a Mouse monoclonal IgG2b antibody highly specific for gamma-cytoplasmic actin. Among the six actin isoforms described in mammals, two are found in virtually all cells (beta- and gamma-cytoplasmic), two are detected in smooth muscle cells (alpha- and gamma-smooth muscle) and two are present in striated muscles, one predominantly in skeletal (alpha-skeletal) and one in cardiac (alpha-cardiac) muscle cells. These actin isoforms differ slightly in their N-terminus, but the sequence of each of these actins is highly conserved in higher vertebRates. beta- and gamma-cytoplasmic actin play crucial roles during various key cellular processes. Whereas beta-actin is preferentially localized in stress fibers, circular bundles and at |
| Immunogen | Source Note: 2A3 is a Mouse monoclonal IgG2b antibody derived by fusion of NS0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a peptide comprising the N-terminal nonapeptide of gamma-cytoplasmic actin with an acetylated N-terminus (Ac-EEEIAALVI-COOH) coupled to keyhole limpet hemocyanin through the cysteine residue. The antibody does not cross react with other actin isoforms. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS570220 |
| Price | $415 |
| Order / More Info | actin gamma-cytoplasmic Antibody from MYBIOSOURCE INC. |
| Product Specific References | Vandekerckhove, J. and Weber, K. (1978). At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol. 126(4), 783-802. Bassell, G.J., Zhang, H., Byrd, A.L., Femino, A.M., Singer, R.H., Taneja, K.L., Lifshitz, L.M., Herman, I.M. and Kosik, K.S. (1998). Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. J Neurosci. 1998 18(1), 251-65. Dugina, V., Zwaenepoel, I., Gabbiani, G., Clement, S. and Chaponnier, C. (2009). beta- and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci 122, 2980-88. Gallant, C., Appel, S., Graceffa, P., Leavis, P., Lin, J.J., Gunning, P.W., Schevzov, G., Chaponnier, C., Degnore, J., Lehman, W. and Morgan, K.G. (2011). Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells. Am J Physiol Cell Physiol. 300(6), 1356-65 |
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