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Antigenic Specificity | SYT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total SYT1 protein. Synaptotagmin 1 (SYT1) is an integral membrane protein found in synaptic vesicles thought to play a role in vesicle trafficking and exocytosis (1). Individual SYT1 proteins are composed of an amino-terminal transmembrane region, a central linker region and a pair of carboxy-terminal C2 domains responsible for binding Ca2+ (2). The C2 domains appear to be functionally distinct, with the C2A domain responsible for regulating synaptic vesicle fusion in a calcium-dependent manner during exocytosis while the C2B domain allows for interaction between adjacent SYT1 proteins (3). Because synaptotagmin 1 binds calcium and is found in synaptic vesicles, this integral membrane protein is tho |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human SYT1. |
Other Names | [SYT1; DKFZp781D2042; P65; SVP65; SYT] |
Gene, Accession # | [SYT1], Gene ID: 6857, NCBI: NP_001129277.1, UniProt: P21579 |
Catalog # | MBS9413367 |
Price | $255 |
Order / More Info | SYT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |