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Antigenic Specificity | Mcl1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, monkey |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 200 ug/ml |
Applications | Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mcl-1 is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-beta1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents. |
Immunogen | Immunogen: Mcl1 antibody was raised in Rabbit using synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1 as the immunogen. |
Other Names | [Rabbit Mcl1; Mcl1; Mcl1; MGC1839; Mcl-1; EAT; mcl1/EAT; Mcl1; MCL1S; MCL1L; MGC104264; Mcl-1; TM; Mcl 1; Mcl 1] |
Gene, Accession # | [Mcl1] |
Catalog # | MBS5311134 |
Price | $430 |
Order / More Info | Mcl1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |