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Antigenic Specificity | CD41a / Integrin alpha2b (Platelet Marker) |
Clone | [ITGA2B/1036] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation. |
Immunogen | Immunogen: Recombinant full-length human Integrin alpha IIb protein |
Other Names | [BDPLT16; BDPLT2; GPalpha IIb; GT; HPA3; Integrin alpha IIb; ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex], [ITGA2B; ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93; GP2B; ITGAB; GPIIb] |
Gene, Accession # | [ITGA2B], Gene ID: 3674, NCBI: NP_000410.2, UniProt: P08514 |
Catalog # | MBS439452 |
Price | $190, $340, $340 |
Order / More Info | CD41a / Integrin alpha2b (Platelet Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995. Smith JW et al. Interaction of integrins v3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271. Du XP et al. Ligands activate integrin IIb/3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416. Law DA et al. Outside-in integrin signal transduction. IIb/3-(GP IIb/IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996, 271(18):10811-10815. Moroi M and Jung SM. Integrin-mediated platelet adhesion. Front Biosci 1998, 3:D719-728 |