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Antigenic Specificity | GSK3B |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human, rat, mouse, monkey |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. |
Immunogen | Immunogen: Purified recombinant fragment of human GSK3B expressed in E. Coli. |
Other Names | [GSK-3beta; GSK3-beta], [GSK3B; GSK3B; GSK-3 beta] |
Gene, Accession # | [GSK3B], Gene ID: 2932, NCBI: NP_001139628.1, UniProt: P49841 |
Catalog # | MBS850776 |
Price | $280 |
Order / More Info | GSK3B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |