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Antigenic Specificity | SOX2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Embryonic stem cells are derived from the inner cell mass of the blastocyst and are unique in their pluripotent capacity and potential for self-renewal. Sox2 is one of a set of transcription factors that are crucial for the maintenance of pluripotency (1). Sox2, Oct-4, and Nanog cooperate in this network (1-3), and siRNA knockdown of either Sox2 or Oct-4 results in loss of pluripotency (4, 5). Chromatin immunoprecipitation experiments have shown that Sox2 and Oct-4 bind to thousands of gene regulatory sites, highlighting the importance of these transcription factors in early embryonic development (6, 7). It has recently been shown that Sox2 is amplified in lung and esophageal squamous cell tumors (8). |
Immunogen | Immunogen: Recombinant protein of human SOX2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [SOX2; ANOP3; MCOPS3; MGC2413] |
Gene, Accession # | [SOX2], Gene ID: 6657, NCBI: NP_003097.1, UniProt: P48431 |
Catalog # | MBS8504836 |
Price | $310 |
Order / More Info | SOX2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Nichols, J. et al. (1998) Cell 95, 379-391. 2. Avilion, A.A. et al. (2003) Genes Dev. 17, 126-140. 3. Rodda, D.J. et al. (2005) J. Biol. Chem. 280, 24731-24737. 4. Matin, M.M. et al. (2004) Stem Cells 22, 659-668. 5. Niwa, H. et al. (2000) Nat. Genet. 24, 372-376. 6. Boyer, L.A. et al. (2005) Cell 122, 947-956. 7. Loh, Y.H. et al. (2006) Nat. Genet. 38, 431-440. 8. Bass, A.J. et al. (2009) Nat Genet 41, 1238-42. |