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Antigenic Specificity | CHOP |
Clone | 2B1 |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CHOP protein detects endogenous levels of DDIT3. DDIT3 (DNA damage inducible transcript 3) encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of DDIT3 and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding |
Immunogen | Immunogen: Synthetic Peptide of CHOP at AA range of 10-90 |
Other Names | [Mouse CHOP Mouse (2B1); DDIT3] |
Gene, Accession # | [CHOP], Gene ID: 1649, NCBI: NP_001181986.1, UniProt: P35638 |
Catalog # | MBS9700546 |
Price | $130, $220, $325 |
Order / More Info | CHOP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |