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Antigenic Specificity | MYD88 |
Clone | [AT22F11] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b,k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Myeloid differentiation primary response gene 88 (MYD88) is adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. |
Immunogen | Immunogen: Recombinant human MYD88 (1-309aa) purified from E. coli |
Other Names | [Myeloid differentiation primary response protein MyD88; MYD88D], [MYD88; MYD88; MYD88D] |
Gene, Accession # | [MYD88], Gene ID: 4615, NCBI: NP_002459, UniProt: Q99836 |
Catalog # | MBS200244 |
Price | $240, $315 |
Order / More Info | MYD88 Antibody from MYBIOSOURCE INC. |
Product Specific References | Bonnert TP, et al. (January 1997). FEBS Letters 402 (1): 81-4.; Lord KA, et al. (1990). Oncogene 5 (7): 1095-7.; Arancibia SA, et al. (2007). Biological research 40 (2): 97-112. |