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Antigenic Specificity | LDL-R |
Clone | polyclonal |
Host Species | Chicken |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | LDL-R Antibody: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD |
Immunogen | Immunogen: LDL-R antibody was raised against an 18 amino acid synthetic peptide near the center of human LDL-R. Buffer: LDL-R Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [LDL-R; FH; FHC; LDLCQ2; Low-density lipoprotein receptor; LDL receptor; low density lipoprotein receptor], [LDLR; LDLR; FH; FHC; LDLCQ2; LDL receptor] |
Gene, Accession # | [LDLR], Gene ID: 3949, NCBI: NP_000518, UniProt: P01130 |
Catalog # | MBS150298 |
Price | $375 |
Order / More Info | LDL-R Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |