Edit |   |
---|---|
Antigenic Specificity | PD-L1/CD274 |
Clone | [RBT-PDL1] |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 5 Control Slides, 3 ml (Prediluted), 0.1 mL (Concentrate) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Programmed death-ligand 1 (PD-L1) also known as CD274 or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other diseases.The upregulation of PD-L1 may allow cancers to evade the host immune system. An analysis of tumor specimens from patients with renal cell carcinoma found that high tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death. Ovarian cancer patients with higher expression of PD-L1 had a significantly po |
Immunogen | Immunogen: Synthetic peptide corresponding to N-terminus residues of the human PD-L1 protein. |
Other Names | n/a |
Gene, Accession # | [PD-L1/CD274] |
Catalog # | MBS370318 |
Price | $130, $315, $345 |
Order / More Info | PD-L1/CD274 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |