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Antigenic Specificity | Tsp23 |
Clone | [Tsp232A] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | ATTO 390 conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects ~19kDa. Detects Tsp23, no cross-reactivity to p23. Scientific Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact funct |
Immunogen | n/a |
Other Names | [Transcript similar p23; AARSD1; AASD1_HUMAN; Alanyl-tRNA editing protein Aarsd1; Alanyl-tRNA synthetase domain containing 1; Alanyl-tRNA synthetase domain-containing protein 1; MGC2744; OTTHUMP00000204017; OTTHUMP00000204019; OTTHUMP00000204020], [PTGES3L; PTGES3L] |
Gene, Accession # | Gene ID: 100885848, NCBI: NP_001136126.1, UniProt: B9A003 |
Catalog # | MBS800231 |
Price | $415 |
Order / More Info | Tsp23 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Johnson J.L., Beito T. G., Krco C.J., Toft D.O. (1994) Mol Cell Biol 14: 1956-63. 2. Weikl T., Abelmann K., Buchner J. (1999) J Mol Biol 293: 685-91. 3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A., Toft D.O. (2000) J Biol Chem 275: 23045-52. 4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50. 5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70. 6. Holt S.E., et al. (1999) Genes Dev 13: 817-26. 7. Hu J., Toft D., Anselmo D., Wang X. (2002) J Virol 76: 269-79. 8. Felts, S.J., Toft D.O. (2003) Cell Stress Chaperones.8: 108- 13. 9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia 10. Freeman B.C., Felts S.J., Toft D.O., Yamamato K.R. (2000) Genes Dev. 14(4): 433-434. |