Phospho-S6K1 (T421 + S424) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-S6K1 (T421 + S424) |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex a |
| Immunogen | Immunogen: A synthesized peptide derived from human Phospho-S6K1 (T421 S424) Subcellular Localization: Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Mitochondrion. Colocalizes with URI1 at mitochondrion. Tissue Specificity: Widely expressed. |
| Other Names | [Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; 2.7.11.1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; RPS6KB1; STK14A] |
| Gene, Accession # | [S6K1], Gene ID: 6198, NCBI: NP_001258971.1, UniProt: P23443 |
| Catalog # | MBS1750265 |
| Price | $160, $340, $340 |
| Order / More Info | Phospho-S6K1 (T421 + S424) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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