Edit |   |
---|---|
Antigenic Specificity | Mouse CD272 |
Clone | [PK18.6] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1k |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of periph |
Immunogen | n/a |
Other Names | [Mouse CD272; B- and T-lymphocyte attenuator; Btla; B- and T-lymphocyte-associated protein; CD272; Btla] |
Gene, Accession # | [CD272], Gene ID: 208154, NCBI: NP_001032808.2, UniProt: Q7TSA3 |
Catalog # | MBS2553789 |
Price | $75, $90 |
Order / More Info | Mouse CD272 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Liu X, et al. 2009. J. Immunol. 182:4516. 2. Miller ML, et al. 2009. J. Immunol. 183:32. 3. Sun Y, et al. 2009. J. Immunol. 183:1946. 4. Vendel AC, et al. 2009. J. Immunol. 182:1509. 5. Watanabe N, et al. 2003. Nat. Immunol. 4:670. |