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Antigenic Specificity | Tau, 4-repeat isoform RD4 (Tau Protein, Microtubule-associated Protein, MAP) |
Clone | [4H380] |
Host Species | Mouse |
Reactive Species | mouse and bovine. |
Isotype | IgG |
Format | supernatant |
Size | 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC). Other applications not tested |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human Tau (4-repeat isoform RD4), Mr 45-65kD. Higher MW band (68-72kD) represents phosphorylated Tau. Microtubule Associated Proteins (MAPS) bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4 and tau,and ar |
Immunogen | Immunogen: Synthetic peptide corresponding to aa275-291, VQIINKKLDLSNVQSKC of human Tau (4-repeat isoform RD4) (Bovine thyroglobulin coupled). Region is flanking junction coded by adjacent exons 9 & 11 with the inclusion of exon 10. |
Other Names | n/a |
Gene, Accession # | NCBI: NP_001116538 |
Catalog # | MBS604301 |
Price | $760 |
Order / More Info | Tau, 4-repeat isoform RD4 (Tau Protein, Microtubule-associated Protein, MAP) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |