Phospho-Mapt-S416 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Mapt-S416 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of o |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S416 of Rat Mapt Calculated Molecular Weight: 48/62/78kDa |
| Other Names | [Phospho-Mapt-S416: pTau; Mtapt; RNPTAU], [Mapt; Mapt; pTau; Mtapt; RNPTAU; Mtapt; Tau; PHF-tau] |
| Gene, Accession # | [Mapt], Gene ID: 29477, NCBI: P19332.3, UniProt: P19332 |
| Catalog # | MBS128389 |
| Price | $235, $350, $525 |
| Order / More Info | Phospho-Mapt-S416 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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