Edit |   |
---|---|
Antigenic Specificity | Apaf1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apaf1 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 |
Immunogen | Immunogen: Apaf1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Apaf1. The sequences of the immunogenic peptide are identical between human and mouse. Buffer: Apaf1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Apaf1; CED4; APAF-1; KIAA0413; Apoptotic protease-activating factor 1; apoptotic peptidase activating factor 1], [APAF1; APAF1; CED4; APAF-1; KIAA0413; APAF-1] |
Gene, Accession # | [APAF1], Gene ID: 317, NCBI: AAC51678, UniProt: O14727 |
Catalog # | MBS150175 |
Price | $375 |
Order / More Info | Apaf1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |