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Antigenic Specificity | ERLIN2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). |
Immunogen | Immunogen: Recombinant human Erlin-2 protein (C-128AA) |
Other Names | [Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2; ERLIN2; C8orf2; SPFH2; UNQ2441/PRO5003/PRO9924] |
Gene, Accession # | [ERLIN2], Gene ID: 11160, NCBI: NP_001003790.1, UniProt: O94905 |
Catalog # | MBS7043698 |
Price | $120, $160 |
Order / More Info | ERLIN2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |