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Antigenic Specificity | Tau (Phospho-Ser214) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of Tau only when phosphorylated at serine 214. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of serine 214 (T-P-S(p)-L-P) derived from Human Tau. |
Other Names | [MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau] |
Gene, Accession # | [Tau], Gene ID: 4137, NCBI: NP_001116538.2, UniProt: P10636 |
Catalog # | MBS9400689 |
Price | $200, $255 |
Order / More Info | Tau (Phospho-Ser214) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |