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Antigenic Specificity | JAG1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms. The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1). Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2). JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3). JAG1 expression is associated with prostate cancer metastasis and is up-regulated |
Immunogen | Immunogen: JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1. Buffer: JAG1 antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Jagged 1; AGS; AHD; AWS; CD339; HJ1; JAGL1; jagged 1], [JAG1; JAG1; AGS; AHD; AWS; HJ1; CD339; JAGL1; JAGL1; Jagged1; hJ1] |
Gene, Accession # | [JAG1], Gene ID: 182, NCBI: NP_000205, UniProt: P78504 |
Catalog # | MBS153705 |
Price | $375 |
Order / More Info | JAG1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |