EGFR Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | EGFR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation (1,2). Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins (3,4). cSrc is involved in phosphorylation of EGFR at Tyr845 (5). The SH2 domain of PLCgamma binds at phosphoTyr992, resulting in activation of PLCgammamediated downstream signaling (6). Phosphorylation of EGFR at Tyr1045 creates a major docking site for the |
| Immunogen | Immunogen: A synthetic peptide of human EGFR |
| Other Names | [EGFR; EGFR; ERBB; ERBB1; HER1; PIG61; mENA;], [EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; ERBB; ERBB1; HER1] |
| Gene, Accession # | Gene ID: 1956, NCBI: NP_005219.2, UniProt: P00533 |
| Catalog # | MBS126363 |
| Price | $275, $430, $655 |
| Order / More Info | EGFR Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hackel, P.O. et al. (1999) Curr Opin Cell Biol 11, 1849. 2. Zwick, E. et al. (1999) Trends Pharmacol Sci 20, 40812. 3. Cooper, J.A. and Howell, B. (1993) Cell 73, 10514. 4. Hubbard, S.R. et al. (1994) Nature 372, 74654. 5. Biscardi, J.S. et al. (1999) J Biol Chem 274, 833543. 6. Emlet, D.R. et al. (1997) J Biol Chem 272, 407986. 7. Levkowitz, G. et al. (1999) Mol Cell 4, 102940. 8. Ettenberg, S.A. et al. (1999) Oncogene 18, 185566. 9. Rojas, M. et al. (1996) J Biol Chem 271, 2745661. 10. Feinmesser, R.L. et al. (1999) J Biol Chem 274, 1616873. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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