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Antigenic Specificity | MAGED1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MAGED1 antibody detects endogenous levels of total MAGED1. Description: MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msxhomeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptiona |
Immunogen | Immunogen: A synthesized peptide derived from human MAGED1 Subcellular Location: Cytoplasm. Cell Membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. Tissue Specificity: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. Predicted Cross Reactivity: Pig, Bovine, Sheep, Rabbit, Dog Similarity: Pig (83%), Bovine (83%), Sheep (83%), Rabbit (100%), Dog (83%) |
Other Names | [DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged1; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250] |
Gene, Accession # | [MAGED1], Gene ID: 9500, NCBI: NP_001005332.1, UniProt: Q9Y5V3 |
Catalog # | MBS9606894 |
Price | $240, $280 |
Order / More Info | MAGED1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |