Edit |   |
---|---|
Antigenic Specificity | Human p62 (pThr269/pSer272) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti Human p62 (pThr269/pSer272) antibody recognizes p62, also known as SQSTM1, when phosphorylated at threonine 269 and serine 272. The protein scaffold and signaling regulator p62 known as sequestosome 1 is encoded for by the SQSTM1 gene. It is important in regulating critical cellular functions, including bone homeostasis, obesity, and cancer via its interactions with various signaling intermediaries. This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. p62 plays an importa |
Immunogen | Antiserum Preparation: Antiserum to p62 (pThr269/pSer272) was raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns. |
Other Names | [Sequestosome-1; Sequestosome-1; sequestosome-1; sequestosome 1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62], [SQSTM1; SQSTM1; p60; p62; A170; OSIL; PDB3; ZIP3; p62B; FTDALS3; ORCA; OSIL; EBIAP; p60] |
Gene, Accession # | [p62], Gene ID: 8878, NCBI: Q13501.1, UniProt: Q13501 |
Catalog # | MBS224870 |
Price | $470 |
Order / More Info | Human p62 (pThr269/pSer272) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |