Edit |   |
---|---|
Antigenic Specificity | BCCIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
Immunogen | Immunogen: Recombinant protein of human BCCIP |
Other Names | [TOK1; TOK-1] |
Gene, Accession # | [BCCIP], Gene ID: 56647, NCBI: NP_057651.1, UniProt: Q9P287 |
Catalog # | MBS9130201 |
Price | $200, $275, $430 |
Order / More Info | BCCIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |