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Antigenic Specificity | OS9 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: OS9 antibody detects endogenous levels of total OS9. Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.Subunit Structure: Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (By similarity). Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly (PubMed:18502753, PubMed:1826409 |
Immunogen | Immunogen: A synthesized peptide derived from human OS9 Subcellular Location: Endoplasmic Reticulum Lumen. Tissue Specificity: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (100%), Zebrafish (82%), Bovi |
Other Names | [Amplified in osteosarcoma 9; amplified in osteosarcoma; ERLEC2; OS-9; Os9; OS9_HUMAN; Osteosarcoma amplified 9 endoplasmic reticulum lectin; Protein OS-9] |
Gene, Accession # | [OS9], Gene ID: 10956, NCBI: NP_001017956.1, UniProt: Q13438 |
Catalog # | MBS9608654 |
Price | $240, $280 |
Order / More Info | OS9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |