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Antigenic Specificity | Presenilin1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid prec |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1. |
Other Names | [PSEN1, PS1, Gamma-secretase subunit presenilin-1] |
Gene, Accession # | Gene ID: 5663, NCBI: NP_000012 |
Catalog # | MBS9402084 |
Price | $320 |
Order / More Info | Presenilin1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |