Edit |   |
---|---|
Antigenic Specificity | RHOB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total RHOB protein. Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human RHOB. |
Other Names | [H6; Rho-related GTP-binding protein RhoB; RHOB; ARH6; ARHB] |
Gene, Accession # | [RHOB], Gene ID: 388, NCBI: NP_004031.1, UniProt: P62745 |
Catalog # | MBS9408400 |
Price | $200, $255 |
Order / More Info | RHOB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |