Edit |   |
---|---|
Antigenic Specificity | DIS3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DIS3 (NP 055768.3). |
Other Names | [RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik] |
Gene, Accession # | [DIS3], Gene ID: 22894, NCBI: NP_055768, UniProt: Q9Y2L1 |
Catalog # | MBS8547200 |
Price | $280 |
Order / More Info | DIS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |