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Antigenic Specificity | TRIM27 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, monkeypredicted: porcine, bovine, horse, sheep, dog |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TRIM27 Antibody detects endogenous levels of TRIM27. Description: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell |
Immunogen | Immunogen: A synthesized peptide derived from human TRIM27. Tissue Specificity: Expressed in testis namely within the seminiferous tubules. |
Other Names | [AW538890; DAAP-182E11.3; MGC189472; OTTHUMP00000029314; Ret finger protein; RFP; RFP transforming protein; Rfp1; RING finger protein 76; RNF76; TRI27_HUMAN; TRIM 27; Trim27; Tripartite motif containing 27; Tripartite motif containing protein 27; Tripartite motif protein TRIM27; Tripartite motif-containing protein 27; Zinc finger protein RFP] |
Gene, Accession # | [TRIM27], Gene ID: 5987, NCBI: NP_006501, UniProt: P14373 |
Catalog # | MBS9611533 |
Price | $240, $280 |
Order / More Info | TRIM27 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |