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Antigenic Specificity | Mouse TIM-1 |
Clone | [RMT1-10] |
Host Species | Rat |
Reactive Species | n/a |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1 mg/ml |
Applications | ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rat anti Mouse TIM-1 antibody, clone MBS239187-10 recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell f |
Immunogen | Immunogen: Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1. Fusion Partners: Lymph node cells from immunised SD rats were fused with cells of the P3U1 myeloma cell line. Buffer Solution: Phosphate buffered saline Target Species: Mouse |
Other Names | [hepatitis A virus cellular receptor 1 homolog isoform b; Hepatitis A virus cellular receptor 1 homolog; hepatitis A virus cellular receptor 1 homolog; HAVcr-1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin mucin receptor 1; TIMD-1; kidney injury molecule 1; t cell immunoglobulin and mucin domain-containing protein 1; t cell membrane protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; TIM-1], [Havcr1; Havcr1; Tim1; KIM-1; TIM-1; Timd1; AI503787; Kim1; Tim1; Timd1; HAVcr-1; KIM-1; TIMD-1; TIM-1] |
Gene, Accession # | [TIM-1], Gene ID: 171283, NCBI: NP_001160103.1, UniProt: Q5QNS5 |
Catalog # | MBS224461 |
Price | $300 |
Order / More Info | Mouse TIM-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |