Immunogen | Immunogen: Tau is a relatively low molecular weight member of the microtubule associated protein or MAP family. Most of these proteins were discovered since microtubules can be polymerized in cell homogenates and pelleted out by centrifugation, typically taking MAP proteins with them (1,2). This early work showed that tau protein facilitated the polymerization of microtubules, and was therefore given the name I'', the Greek letter tau, since it promoted tubule formation. The protein is now usuall |
Product Specific References | 1. Weingarten, M. D., Lockwood, A. H., Hwo, S.-Y. and Kirschner, M. W. A protein factor essential for microtubule assembly. Proc. Nat. Acad. Sci. USA 72:1858 -1862 (1975).2. Cleveland, D. W., Hwo, S. Y., Kirschner, M. W. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 116:207-25 (1977).3. Goedert, M., Spillantini, M. G. A century of Alzheimer's disease. Science 314:777 -781 (2006).4. Ballatore, C., Lee, V. M., Trojanowski, J. Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci. 8:663 -672 (2007).5. Wolfe, M. S. Tau mutations in neurodegenerative diseases. J. Biol. Chem. 284:6021-6025 (2009).6. Goedert M, Spillantini MG, Crowther RA. Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc Natl Acad Sci U S A. 89:1983-7 (1992).7. Boyne LJ, Tessler A, Murray M, Fischer I. Distribution of Big tau in the central nervous system of the adult and developing rat. J. Comp. Neurol. 358:279-93 (1995). |