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Antigenic Specificity | GPR18 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GPR18 antibody detects endogenous levels of total GPR18. Function: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cell Membrane; Multipass Membrane Protein. Tissue Specificity: Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083). Predicted Cross Reactivity: Horse, Rabbit, Dog Similarity: Horse (82%), Rabbit (82%), Dog (80%) |
Other Names | [G protein coupled receptor 18; GPCRW; GPR 18; GPR18; N arachidonyl glycine receptor; NAGly receptor] |
Gene, Accession # | [GPR18], Gene ID: 2841, NCBI: NP_001091670.1, UniProt: Q14330 |
Catalog # | MBS9606356 |
Price | $240, $280 |
Order / More Info | GPR18 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |