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Antigenic Specificity | TNFAIP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB (1, 2). It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs (3). Constitutive expression of A20 is observed in lymphoid tissues (4), but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha (3, 5), IL-1 (3, 5), phorbol esters (6), and LPS (7). Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF r |
Immunogen | Immunogen: Recombinant protein of human TNFAIP3 Observed Molecular Weight: 90kDa |
Other Names | [A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2] |
Gene, Accession # | [TNFAIP3], Gene ID: 7128, NCBI: NP_001257437.1 |
Catalog # | MBS2522794 |
Price | $150, $225, $360 |
Order / More Info | TNFAIP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |