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Antigenic Specificity | Phospho-Chk2 (Ser516) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, monkey |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB); ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect endogenous levels of Chk2 (pS516) in human and monkey samples. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest; activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation; phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A; CDC25B and CDC25C; inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progress |
Immunogen | Immunogen: Synthesized peptide derived from human Chk2 around the phosphorylation site of S516 |
Other Names | [Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2; CHEK2], [CHEK2] |
Gene, Accession # | [Chk2], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
Catalog # | MBS846142 |
Price | $335 |
Order / More Info | Phospho-Chk2 (Ser516) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |