Edit |   |
Antigenic Specificity | MKI67 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4). |
Immunogen | Immunogen: Recombinant protein of human MKI67 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [MKI67; KIA; Antigen KI-67; Ki-67] |
Gene, Accession # | [MKI67], Gene ID: 4288, NCBI: NP_001139438.1, UniProt: P46013 |
Catalog # | MBS8504599 |
Price | $310 |
Order / More Info | MKI67 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Gerdes, J. et al. (1983) Int J Cancer 31, 13-20. 2. Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62. 3. Jones, R.L. et al. (2009) Breast Cancer Res Treat 116, 53-68. 4. Yerushalmi, R. et al. (2010) Lancet Oncol 11, 174-83. |