CD40 [5D12] Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD40 [5D12] |
| Clone | [5D12] |
| Host Species | Human |
| Reactive Species | cynomolgus, marmoset monkey, human |
| Isotype | IgG4, kappa |
| Format | Protein A purified |
| Size | 0.2 mg |
| Concentration | 1 mg/ml |
| Applications | Block (BL), ELISA (EIA), Flow Cytometry (FC/FACS), Surface Plasmon Resonance (SPR), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: ch5D12 binds specifically to recombinant and native human CD40 ectodomain and has been shown to also bind CD40 in cynomolgus and marmoset monkeys. The antibody requires residues within D1 and D1/B2 for binding (Hager et al, 2003) (D1 domain is crucial for CD40L binding). Binding characteristics are very similar between humanized ch5D12 and mu5D12. CD40 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40 binds to CD40L, and this interaction is involved in B-cell activation and proliferation, antigen-presenting cell (APC) activation, initiation of antigen-specific T-cell responses, immunoglobul |
| Immunogen | Immunogen: Anti-CD40 mAb 5D12, was generated by immunizing mice with sf9 insect cells expressing recombinant human CD40 and selected for the ability to bind EBV-immortalized human B cells. The variable regions from mu5D12 were cloned and used to construct chimeric humanized IgG4 5D12. |
| Other Names | [Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40], [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5] |
| Gene, Accession # | [CD40], Gene ID: 958, NCBI: NP_001241.1, UniProt: P25942 |
| Catalog # | MBS488353 |
| Price | $425 |
| Order / More Info | CD40 [5D12] Antibody from MYBIOSOURCE INC. |
| Product Specific References | Boon et al. Preclinical assessment of anti-CD40 Mab 5D12 in cynomolgus monkeys Toxicology. 2002 May 15; 174(1):53-65. PMID:11972992 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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