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Antigenic Specificity | Phospho-ERK3-S189 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region (1). However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, possessing instead an SEG motif (1,2). Phosphorylation at Ser189 in the SEG motif has been reported (2,3). With limited information about its upstream kinases and downstream substrates, the significance of this phosphorylation remains to be elucidated (3,4). Erk3 is an inherently unstable protein, rapidly degraded through amino-terminal ubiquitination and proteasome degradation (3,5). A site-specific cleavage, depending on a short stretch of acidic residues of Erk3, might regulate its trans |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S189 of human ERK3 |
Other Names | [Phospho-MAPK6-S189: DKFZp686F03189; ERK3; HsT17250; PRKM6; p97MAPK; MAPK6], [MAPK6; MAPK6; ERK3; PRKM6; p97MAPK; HsT17250; ERK3; PRKM6; MAP kinase 6; MAPK 6; ERK-3; p97-MAPK] |
Gene, Accession # | [MAPK6], Gene ID: 5597, NCBI: Q16659.1, UniProt: Q16659 |
Catalog # | MBS125434 |
Price | $235, $350, $525 |
Order / More Info | Phospho-ERK3-S189 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |