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Antigenic Specificity | KLF7 |
Clone | [AT3G3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | KLK7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation, survival and the development of nervous systems.and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 is binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: Recombinant human KLF7 (1-302aa) purified from E. coli |
Other Names | [Kruppel-like factor 7; uKLF], [KLF7; KLF7; UKLF; UKLF] |
Gene, Accession # | [KLF7], Gene ID: 8609, NCBI: NP_003700, UniProt: O75840 |
Catalog # | MBS200270 |
Price | $240, $315 |
Order / More Info | KLF7 Antibody from MYBIOSOURCE INC. |
Product Specific References | Matsumoto, N., et al. (1998) J Biol Chem 273 (43): 28229-37; Kanazawa, A., et al. (2005) Diabetologia 48 (7): 1315-22 |