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Antigenic Specificity | Cyclin E |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes 62 kDa of Cyclin B1 Protein. It reacts with human, mouse and rat. The other species are not tested. Cyclin B1 is a regulatory protein involved in mitosis. Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation of Cdk1 by the Wee1 kinase. The complex is activated by dephosphorylation by the phosphatase Cdc25. Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. At the end of mitosis, cyclin B1 is targeted for degradation by the APC through its APC localization sequence permitting to exit mitosis. Cyclin B1/Cdc2 complexes, which appear to be con |
Immunogen | n/a |
Other Names | [CCNE], [CCNE1; CCNE1; CCNE; pCCNE1; CCNE] |
Gene, Accession # | Gene ID: 898, NCBI: AAA83269.1 |
Catalog # | MBS460183 |
Price | $285 |
Order / More Info | Cyclin E Antibody from MYBIOSOURCE INC. |
Product Specific References | Miyazaki, T. Arai, S. Two distinct controls of mitotic cdk1/cyclin B1 activity requisite for cell growth prior to cell division. Cell Cycle. 6 (12):1419-25 (2007). |