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Antigenic Specificity | Phospho-TBK (S172) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human; predicted: zebrafish, mouse, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | n/a |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK. Background: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.Fun |
Immunogen | n/a |
Other Names | [Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1; TBK1; NAK] |
Gene, Accession # | [TBK1], Gene ID: 29110, NCBI: NP_037386.1, UniProt: Q9UHD2 |
Catalog # | MBS9200702 |
Price | $165, $370 |
Order / More Info | Phospho-TBK (S172) Antibody from MYBIOSOURCE INC. |
Product Specific References | Deng,W., J. Biol. Chem. 283 (51), 35590-35597 (2008) Chessler,A.D., J. Immunol. 181 (11), 7917-7924 (2008) Soulat,D., EMBO J. 27 (15), 2135-2146 (2008) |