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Antigenic Specificity | DIS3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.5mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total DIS3 protein. The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3' to 5' exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3' regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progressi |
Immunogen | Immunogen: Synthetic peptide of human DIS3 Immunogen Type: Peptide |
Other Names | [RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik] |
Gene, Accession # | [DIS3], Gene ID: 22894, NCBI: NP_055768, UniProt: Q9Y2L1 |
Catalog # | MBS9430007 |
Price | $255 |
Order / More Info | DIS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |