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Antigenic Specificity | Phospho-SEK1/MKK4 (Ser80) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-SEK1/MKK4 (Ser80) antibody detects endogenous levels of SEK1/MKK4 only when phosphorylated at Serine 80. Description: MKK4 dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and-2 as well as p38 but not ERK1 or-2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly ac |
Immunogen | Immunogen: A synthesized peptide derived from human SEK1/MKK4 around the phosphorylation site of Serine 80 Subcellular Location: Nucleus Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%) |
Other Names | [c Jun N terminal kinase kinase 1; C-JUN N-terminal kinase kinase 1; Dual specificity mitogen activated protein kinase kinase 4; Dual specificity mitogen-activated protein kinase kinase 4; JNK Activated Kinase 1; JNK activating kinase 1; JNK-activating kinase 1; JNKK; JNKK1; MAP kinase kinase 4; Map2k4; MAPK ERK kinase 4; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; Mitogen activated protein kinase kinase 4; MKK 4; MKK4; MP2K4_HUMAN; PRKMK4; SAPK ERK kinase 1; SAPK/ERK kinase 1; SAPKK 1; SAPKK1; SEK1; SERK1; SKK1; Stress activated protein kinase kinase 1] |
Gene, Accession # | [SEK1/MKK4], Gene ID: 6416, NCBI: NP_001268364.1, UniProt: P45985 |
Catalog # | MBS9601090 |
Price | $240, $280 |
Order / More Info | Phospho-SEK1/MKK4 (Ser80) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |